What Is Tirzepatide Plus⁺?
the NewSelf program's Tirzepatide Plus⁺ combines compounded tirzepatide — the same active molecule as Mounjaro and Zepbound — with either Pyridoxine (Vitamin B6) or Glycine. Both are standard compounding pharmacy additives that serve as nutritional support during intensive metabolic weight loss.
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Why B6 (Pyridoxine) Is Added
Pyridoxine (Vitamin B6) is an essential coenzyme involved in over 100 enzymatic reactions in the body — including amino acid metabolism, neurotransmitter synthesis (serotonin, dopamine), glycogen breakdown, and immune function. During the significant caloric restriction and metabolic adaptation that accompanies tirzepatide-driven weight loss, demand for B6 as a metabolic cofactor increases. The addition supports energy metabolism, protein utilization, and may help buffer the mood and energy fluctuations some patients experience during early program weeks.
Glycine as Alternative Additive
Glycine serves a dual pharmaceutical and metabolic role in the Tirzepatide Plus⁺ formulation. Pharmaceutically, Glycine acts as a stabilizing buffer — helping maintain tirzepatide's molecular integrity in aqueous solution over the shelf life. Metabolically, Glycine supports collagen synthesis (relevant during fat loss and body composition change), liver function (through glutathione synthesis), and may mildly support sleep quality at therapeutic doses. The choice between B6 and Glycine is made at the pharmacy level — both are safe, well-studied additives with complementary supporting roles.
Does the Additive Affect Tirzepatide Efficacy?
No clinical trial has studied B6-enhanced or Glycine-enhanced tirzepatide vs tirzepatide alone. The SURMOUNT-1 trial's 22.5% average weight loss figure was achieved with plain tirzepatide — the additives do not enhance GLP-1/GIP receptor activity or independently produce weight loss. Evaluate NewSelf's GLP-1 platform primarily on tirzepatide's established dual receptor mechanism. The additives are nutritional support — not active weight-loss agents. See our clinical sources.